Check It, Change It

Check it out!

Check it, change it: a community-based, multifaceted intervention to improve blood pressure control.

BACKGROUND Although home blood pressure (BP) monitoring interventions have shown potential in selected populations, it is unclear whether such strategies can be generalized. We sought to determine whether a multifaceted BP control program that uses a web-based health portal (Heart360), community health coaches, and physician assistant guidance could improve hypertension control in a diverse com...

Check it, change it: a community-based intervention to improve blood pressure control.

BACKGROUND Despite the widespread availability of effective and affordable therapies, hypertension remains this country's most significant modifiable cardiovascular risk factor. Approximately 30% to 50% of individuals with hypertension currently fail to reach guideline-recommended target blood pressure (BP) goals. Although multiple interventions have been proposed to affect better hypertension ...

BCC or not: Sufu keeps it in check

Basal cell carcinoma (BCC), driven by aberrantly activated HEDGEHOG (HH) pathway, is the most common human malignancy. Current FDA-approved targeted therapy uses Vismodegib to inhibit SMO, a membrane component of the HH pathway. Despite initial impressive tumor regression, the positive clinical response is short-lived in some BCC patients as acquired SMO mutations confer secondary resistance[1]...

Holding the inflammatory system in check: NLRs keep it cool

Inflammation is a double-edged sword. While short-lived, acute inflammation is essential for the repair and resolution of infection and damage, uncontrolled and unresolved chronic inflammation is central to several diseases, including cancer, autoimmune diseases, allergy, metabolic disease, and cardiovascular disease. This report aims to review the literature regarding several members of the nu...